منابع مشابه
Vitamin D: Proteases, protease inhibitors and cancer.
The active vitamin D metabolite 1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3), Calcitriol) is a major regulator of gene expression in higher organisms. Protein abundance is an endpoint of gene expression that results from the balance between induction and degradation and is essential for adequate cell function. Proteins are degraded by proteases whose activity is in turn controlled by a numb...
متن کاملProteases and Protease Inhibitors: Implications in Antitumorigenesis and Drug Development
The role of proteases in cancer is far more complex than initially anticipated and include tumor promoting as well as suppressive effects and their inhibitors are emerging with promising therapeutics in cancer treatment. Proteases are involved in tumor growth both at the primary and metastatic sites. Inhibitors of all the five classes of proteases (serine, aspartyl, cysteine, metalloand threoni...
متن کاملComprehensive transcriptome of proteases and protease inhibitors in vascular cells.
BACKGROUND AND PURPOSE Smooth muscle cells, endothelial cells, and macrophages are essential components of the vasculature, of which the homeostatic gene expression participate importantly in the maintenance of vascular wall integrity. The pathogenesis of vascular diseases, such as cerebral ischemia, atherosclerosis, and abdominal aortic aneurysms, often associates with inflammation and altered...
متن کاملA genomic analysis of rat proteases and protease inhibitors.
Proteases perform important roles in multiple biological and pathological processes. The availability of the rat genome sequence has facilitated the analysis of the complete protease repertoire or degradome of this model organism. The rat degradome consists of at least 626 proteases and homologs, which are distributed into 24 aspartic, 160 cysteine, 192 metallo, 221 serine, and 29 threonine pro...
متن کاملStudy of Proteases and Protease Inhibitors from Streptomyces Strains
KALCHEV, K., Y. RABADJIEV, D. GANCHEV, M. TSENOVA, I. ILIEV and I. IVANOVA, 2013. Study of proteases and protease inhibitors from Streptomyces strains. Bulg. J. Agric. Sci., Supplement 2, 19: 65–67 Proteases and protease inhibitors are important enzymes in Streptomyces physiology and differentiation. The objective of this paper was to investigate the optimal conditions for production of proteas...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1967
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(19)34138-1